Professor Vasso Apostolopoulos, Dr Dodie Pouniotis, A/Professor Christine McDonald
Macfarlane Burnet Institute for Medical Research and Public Health
Lung cancer is the leading cause of death due to cancer in
Australia. One in 20 men and 1 in 47 women will develop lung cancer in
their lifetime. Unfortunately, once diagnosed with advanced lung
cancer, patients only tend to live a few months.
detection methods such as chest x-ray or CT scan do not appear to have
much impact on either treatment or number of deaths, therefore, more
research is needed in other aspects of lung cancer.
study will aim to identify potential defects in the immune response of
lung cancer patients compared to healthy patients. The specific defects
identified in this study will allow us to potentially manipulate the
immune system via novel treatments that could potentially prolong life
expectancy and decrease mortality associated with this disease.
outcomes of this project are to identify which aspects of the function
of pulmonary macrophages is defected. Pulmonary macrophages are the
main cells in the lung which engulf foreign particles and dead cells.
They are an important part of the immune system for defense against
cancer and potential infections in the lung.
Award / Duration
Research Grant: 2007