Dr Kate Murphy, Prof John Silke, Prof Gordon Lynch, Prof Leanne Delbridge
The University of Melbourne
What is the project?
We will test the therapeutic potential of novel antibodies for reducing the heart failure associated with many cancers and chemotherapeutics. Our results will lead to better treatment approaches and improved health outcomes for cancer patients.
What are you trying to achieve?
There is an urgent need to treat the heart failure associated with many cancers, and to prevent the toxic effects that chemotherapies can have on the heart. We discovered that a certain type of signalling contributes to skeletal muscle wasting and weakness in cancer. This proposal will investigate whether this signalling pathway is similarly implicated in the development of heart failure in cancer and with chemotherapy, and whether blocking this pathway can improve health outcomes.
Cancer Council Victoria Research Grant