Lead researcher
Dr Andrew Deans, Dr Alessandro Costa
Institution
Genome Stability Unit, St Vincent's Institute of Medical Research
Years funded
2015-2016
An inherited, leukaemia-prone disorder called
Fanconi anemia is caused by a defect in the FANCM gene. This means FANCM is a
“tumour suppressor”, and our project will characterise how FANCM works to
prevent normal cells becoming cancer. On the other hand, FANCM also works to
protect cancer cells from chemotherapy. We are developing a way to inhibit
FANCM, so that cancer cells can be better killed by chemotherapy. Our study
therefore has implications for both the cause and treatment of cancer.
Lay report:
A new target in the chemosensitisation of tumour cells
Funding Body
Cancer Council Research Grant
Funding
$100,000 per annum