Lead researcher
Dr Colin Clyne, Dr Ashwini Chand, Prof Evan Simpson
Institution
Cancer Drug Discovery, Hudson Institute of Medical Research
Years funded
2015-2017
New therapeutic targets for breast cancer are
urgently required. This application focuses on a protein known as LRH-1, which
we have previously shown to mediate oestrogen production in breast tissues. We
will show that LRH-1 stimulates breast cancer proliferation in animal and
preclinical models, and demonstrate the utility of blocking LHR-1 function,
using novel inhibitors, as breast cancer therapy.nuclear receptors, endocrinology, cell proliferation,
transgenic mouse, mammary gland cancer.
Funding Body
Cancer Council Research Grant
Funding
$100,000 per annum