Interfering with a novel immune checkpoint to treat malignant melanoma

Lead researcher

Dr Andreas Behren, Dr Katherine Woods, Prof Jonathan Cebon

Cancer Immunobiology, Olivia Newton-John Cancer Research Institute

Years funded

Melanoma is responsible for the majority of skin cancer related deaths and its incidence is rising. Strategies to harness the body's own immune system have shown promising anti-tumour effects, however, only a group of patients shows a response. We identified a novel molecule in melanoma that may block the immune system from efficiently destroying the tumour. This application aims to understand and interfere with the immune-suppressive action of this protein to create new therapeutic options.

Lay Report:

Funding Body

Cancer Council Research Grant