Head and neck cancer may be treated in different ways, depending on the type, location and stage of the cancer, your general health and what is important to you. The key treatments for head and neck cancers are surgery, radiation therapy and chemotherapy, which you may have alone or in combination.
Treatment will be tailored to your individual situation. For complex head and neck cancer, treatment options should be discussed at a meeting of the multidisciplinary team (MDT) in a specialised centre.
Preparing for treatment
It is important to look after your health before treatment begins. This will help you cope with side effects and can improve treatment outcomes.
- Stop smoking – aim to quit before starting treatment. See your doctor or call the Quitline on 13 7848.
- Begin or continue an exercise program – exercise will help build up your strength for recovery.
- Improve your diet and nutrition – a dietitian can suggest ways to maintain your weight during treatment, which will help improve your strength and may mean the treatment works better.
- Avoid alcohol – alcohol can irritate mouth sores caused by the cancer or treatment.
- See a dentist – treatments for head and neck cancer can affect your mouth, gums and teeth. Your specialist may refer you to a special needs dentist who understands the treatments you will be having. You will need a full check-up and an oral health care plan covering any dental work you need and how to care for your mouth.
- Consider the costs – there can be lots of extra costs during cancer treatment. Your health care providers should talk to you about how much you’ll pay for tests, treatments, medicines and hospital care. This is called informed financial consent.
Your guide to best cancer care
A lot can happen in a hurry when you’re diagnosed with cancer. The guide to best cancer care for head and neck cancer can help you make sense of what should happen. It will help you with what questions to ask your health professionals to make sure you receive the best care at every step.
Read the guide
The aim of surgery is to completely remove the cancer and preserve the functions of the head and neck area, such as breathing, swallowing and talking. It is often used as the main treatment for head and neck cancer.
The surgeon will cut out the cancer and a margin of healthy tissue, which is checked by a pathologist to make sure all the cancer cells have been removed. Often some lymph nodes will also be removed.
How the surgery is done
Different surgical methods may be used to remove the cancer. Your doctor will advise which method is most suitable for you. The options may include:
- endoscopic surgery – a rigid instrument with a light and camera is inserted through the nose or mouth so the surgeon can see and remove some cancers, particularly from the nose and sinuses.
- transoral laser microsurgery (TLM) – a microscope usually with a laser attached is used through the mouth to remove cancers, particularly of the larynx and lower throat.
- transoral robotic surgery (TORS) – the surgeon uses a 3D telescope and instruments attached to robotic arms to reach the cancer through the mouth. It is often used for oropharyngeal cancers.
- open surgery – the surgeon makes cuts in the skin of the head and neck to reach and remove cancers. It is used for larger cancers and those in difficult positions. Part of the upper and lower jaw or skull may need to be removed and then replaced or reconstructed.
Minimally invasive surgery such as endoscopic, TLM and TORS usually means less scarring, a shorter hospital stay and faster recovery. However, these types of surgery are not possible in all cases, and open surgery is often the best option in many situations.
After open surgery, you may need reconstructive surgery to help with your swallowing and to improve how the area looks. It is usually part of the same operation but is sometimes done later.
Reconstructive surgery uses a combination of skin, muscle and occasionally bone to rebuild the area. This can be taken from another part of the body and is called either a free flap or a regional flap. Occasionally synthetic materials such as silicone and titanium are used to re-create bony areas or other structures in the head and neck. This is called a prosthetic.
Surgery for oral cancer
The type of surgery depends on the cancer’s size and location. Localised cancers can be treated by removing part of the tongue, mouth or lip. For larger cancers, the surgery will affect a bigger area and you may need reconstructive surgery so you can continue to chew, swallow or speak.
Some tumours can be removed through the mouth, but you may need open surgery for larger tumours. Different types of oral surgery include:
- glossectomy – removes part or all of the tongue
- mandibulectomy – removes part or all of the lower jaw (mandible)
- maxillectomy – removes part or all of the upper jaw (maxilla).
Surgery for pharyngeal cancer
Pharyngeal cancers are treated differently depending on which part of the pharynx is affected. Surgery is used for many oropharyngeal and hypopharyngeal cancers. Nasopharyngeal cancers are usually treated with radiation therapy and rarely treated with surgery.
Small oropharyngeal and hypopharyngeal cancers can often be treated with minimally invasive surgery, sometimes followed by radiation therapy with or without chemotherapy. If the cancer is large or advanced and surgery is an option, it is more likely to be open surgery through a cut in the neck.
Surgery is often followed with radiation therapy and possibly chemotherapy. Different types of pharyngeal surgery include:
- oropharyngectomy – removes some of the oropharynx (the part of the throat behind the mouth)
- hypopharyngectomy – removes part of the hypopharynx (the lower throat)
- laryngopharyngectomy – removes all of the larynx and most of the pharynx. This surgery is less common and is similar to a total laryngectomy.
Surgery for laryngeal cancer
If laryngeal cancer is at an early stage, you may have surgery to remove part of the larynx (partial laryngectomy). The surgery may be minimally invasive or open. It often takes up to six months for the voice to recover. In some cases, the changes to the voice may be permanent.
If the cancer has advanced, you may need open surgery to remove the larynx (total laryngectomy). This operation removes the whole larynx and separates the windpipe (trachea) from the food pipe (oesophagus).
After this surgery, you will permanently breathe through a hole in the front of your neck called a laryngectomy stoma. Because this surgery removes the voice box, you won’t be able to speak in the same way. A speech pathologist will teach you new ways to talk and communicate.
If you have a total laryngectomy, part or all of your thyroid gland may be removed (thyroidectomy). The thyroid produces thyroxine (T4), the hormone that controls your metabolism, energy levels and weight, so you may need to take thyroid hormone replacement tablets every day for the rest of your life. Talk to your doctor for more details.
Surgery for nasal or paranasal sinus cancer
Your doctor may advise you to have surgery if the tumour isn’t too close to your brain or major blood vessels. The type of surgery will depend on where the tumour is and, if you have paranasal sinus cancer, which sinuses are affected.
Different types of surgery for nasal and sinus cancer include:
- maxillectomy – removes part or all of the upper jaw (maxilla), which may include the upper teeth, part of the eye socket and/or the nasal cavity.
- skull base surgery – also known as a craniofacial resection, this surgery removes part of the nasal cavity or sinuses. It is often done endoscopically through the nose, but a cut along the side of the nose may be needed.
- orbital exenteration – removes the eye and may also remove tissue around the eye socket.
- rhinectomy – removes part or all of the nose.
The surgeon will consider how the operation will affect how you look, and your ability to breathe, speak, chew and swallow. If your nose, or a part of it, is removed, you may get an artificial nose (prosthesis) or the nose may be reconstructed using tissue from other parts of your body.
Surgery for salivary gland cancer
Most salivary gland tumours affect one of the parotid glands, which sit in front of the ears. Surgery to remove part or all of a parotid gland is called a parotidectomy.
The facial nerve runs through the parotid gland. This nerve controls facial expressions and movement of the eyelid and lip. If it is damaged during surgery, you may be unable to smile, frown or close your eyes. This is known as facial palsy, and it will usually improve over several months.
In some cases, the facial nerve needs to be cut so the cancer can be removed. This will affect how your face looks and moves. There are various procedures that can help improve this, such as using a nerve from another part of the body (nerve graft).
If the cancer affects a gland under the lower jaw (submandibular gland) or under the tongue (sublingual gland), the gland will be removed, along with some surrounding tissue. Nerves controlling the tongue and lower part of the face may be damaged, causing some loss of function.
Removing lymph nodes
If the cancer has spread to the lymph nodes in your neck, or it is highly likely to spread, your surgeon will probably remove some lymph nodes. This operation is called a neck dissection or lymphadenectomy.
Most often lymph nodes are removed from one side of the neck, but sometimes they need to be removed from both sides. A neck dissection may be the only surgery needed, or it may be part of a longer head and neck operation.
A neck dissection may affect how your shoulder moves and your neck looks after surgery. A physiotherapist can help improve movement and function.
What to expect after surgery
How you feel after surgery will vary greatly depending on your age, general health, how large an area is affected and whether you also have reconstructive surgery. Your surgeon can give you a better idea of what to expect after the operation.
Staying in hospital
How long you stay in hospital depends on the type of surgery you have, the area affected, and how well you recover. Surgery to remove some small cancers can often be done as a day procedure. Recovery is usually fast and there are often few long-term side effects.
Surgery for more advanced cancers often affects a larger area, can involve reconstructive surgery and may last all day. You may need care in the intensive care unit before being transferred to the ward, and side effects may be long term or permanent.
Once you return home, you may be able to have nurses visit to provide follow-up care.
Most surgeries for head and neck cancer will have some short-term side effects, such as discomfort, pain and a sore throat. Recovery after larger surgeries may be more challenging, especially at first. You may have a temporary catheter or feeding tube, and experience speech changes and swallowing difficulties.
Long-term side effects can include changes to energy levels, eating, speaking, breathing, appearance, sexuality, vision and hearing, as well as ongoing pain and lymphoedema.
Talk to your treatment team about what to expect and get support from a physiotherapist, speech pathologist and/or dietitian.
Radiation therapy uses a controlled dose of radiation to kill or damage cancer cells. For head and neck cancer, the radiation is usually in the form of x-ray beams that come from a machine outside the body.
This is called external beam radiation therapy (EBRT), and it is often delivered using a technique called intensity modulated radiation therapy (IMRT). This technique targets the radiation precisely to the cancer, which reduces treatment time and causes as little harm as possible to nearby healthy tissue.
- As the main treatment – for some pharyngeal and laryngeal cancers, radiation therapy will be the main treatment, with the aim of destroying the cancer while maintaining normal speech, swallowing and breathing. Sometimes chemotherapy will also be used to make the radiation work better (chemoradiation).
- After surgery – radiation therapy is often used after surgery for head and neck cancers (adjuvant treatment). The aim is to destroy any remaining cancer cells and reduce the chance of the cancer coming back. Adjuvant radiation therapy is sometimes given together with chemotherapy (chemoradiation).
Radiation therapy is carefully planned and you usually won't need to stay in hospital. It is painless and is usually given Monday to Friday for 6–7 weeks.
You will be fitted for a plastic mask called an immobilisation mask, which you will wear for 10–20 minutes at each session. The mask helps you keep still and ensures the radiation is targeted at the same area.
Side effects of radiation therapy
Radiation therapy side effects vary depending on the area treated, the number of sessions, and whether it is combined with chemotherapy. Side effects may include fatigue, mouth sores, swallowing difficulties and skin redness, among others.
Side effects often get worse 2–3 weeks after treatment ends and then start to improve. Some side effects may last longer, be ongoing or appear several months or years later, such as muscle stiffness, neck swelling, appetite and weight loss and hair loss, among others.
- Aspiration – some people develop a temporary or ongoing problem where fluid or food enters the windpipe while swallowing. This is called aspiration and it can cause coughing, lung infections such as pneumonia and, sometimes, difficulty breathing.
- Thyroid damage – if the treatment damages the thyroid, it can cause an underactive thyroid (hypothyroidism), which can be managed with thyroid hormone replacement tablets.
- Osteoradionecrosis of the jaw – radiation therapy can damage blood vessels, reducing the blood supply to the area treated. Occasionally, the bone starts to die, leading to pain, infection and fractures. This is known as osteoradionecrosis or ORN, and it affects about 5–7% of people who have radiation therapy to the head and neck. It can occur months or years later, most commonly after having dental work. Treatment for ORN may include antibiotics, other medicines or surgery.
It is important to see a dentist before your cancer treatment and to tell them if you've had radiation therapy in the past.
Chemotherapy is the use of drugs to kill or slow the growth of cancer cells. The aim is to destroy cancer cells while causing the least possible damage to healthy cells. You will usually receive chemotherapy by injection into a vein (intravenously), although it is occasionally given as tablets.
Chemotherapy may be given for a range of reasons:
- in combination with radiation therapy (chemoradiation), to increase the effects of radiation
- before surgery or radiation therapy (neoadjuvant chemotherapy), to shrink a tumour
- after surgery (adjuvant chemotherapy), along with radiation therapy, to reduce the risk of the cancer returning
- as palliative treatment to relieve symptoms such as pain.
Everyone reacts differently to chemotherapy, and side effects will vary according to the drugs you are given. Some people may have few, while others have many. Common side effects include fatigue, nausea, low red blood cell count, hearing loss, diarrhoea or constipation and hair loss, among others.
Other drug therapies
In certain situations, you may be offered targeted therapy or immunotherapy, which work in different ways to chemotherapy. They will usually be combined with other treatments such as radiation therapy.
- Targeted therapy – targets specific features of cancer cells to stop the cancer growing and spreading. For some head and neck cancers, a targeted therapy drug called cetuximab is occasionally used when people cannot take the standard chemotherapy drug or the cancer is advanced.
- Immunotherapy – uses the body’s own immune system to fight cancer. The main type of immunotherapy in Australia uses drugs known as checkpoint inhibitors, which help the immune system to recognise and attack cancer cells. Nivolumab is a checkpoint inhibitor used to treat some types of advanced head and neck cancer.
Other targeted therapy and immunotherapy drugs are being studied in clinical trials. Talk with your doctor about the latest developments and whether a clinical trial would be an option for you.
In some cases of very advanced head and neck cancer, the medical team may talk to you about palliative treatment. Palliative treatment aims to improve your quality of life by managing the symptoms without trying to cure the disease.
When used as palliative treatment, radiation therapy, chemotherapy or other drug therapies can help manage pain and other symptoms, and may also slow the spread of the cancer. It is one aspect of palliative care, in which a team of health professionals aims to meet your physical, emotional, cultural, spiritual and social needs. The team also supports families and carers.
Understanding Head and Neck Cancers
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Expert content reviewers:
A/Prof Richard Gallagher, Head and Neck Surgeon, Director of Cancer Services and Head and Neck Cancer Services, St Vincent’s Health Network, NSW; Dr Sophie Beaumont, Head of Dental Oncology, Dental Practitioner, Peter MacCallum Cancer Centre, VIC; Dr Bena Brown, Speech Pathologist, Princess Alexandra Hospital, and Senior Research Fellow, Menzies School of Health Research, QLD; Dr Teresa Brown, Assistant Director, Nutrition and Dietetics, Royal Brisbane and Women’s Hospital, QLD; Lisa Castle-Burns, Head and Neck Cancer Specialist Nurse, Canberra Region Cancer Centre, The Canberra Hospital, ACT; A/Prof Ben Chua, Radiation Oncologist, Royal Brisbane and Women’s Hospital, GenesisCare Rockhampton and Brisbane, QLD; Elaine Cook, 13 11 20 Consultant, Cancer Council Victoria; Dr Andrew Foreman, Specialist Ear, Nose and Throat Surgeon, Royal Adelaide Hospital, SA; Tony Houey, Consumer; Dr Annette Lim, Medical Oncologist and Clinician Researcher – Head and Neck and Non-melanoma Skin Cancer, Peter MacCallum Cancer Centre and The University of Melbourne, VIC; Paula Macleod, Head, Neck and Thyroid Cancer Nurse Coordinator, Northern Sydney Cancer Centre, Royal North Shore Hospital, NSW; Dr Aoife McGarvey, Physiotherapist and Accredited Lymphoedema Practitioner, Physio Living, Newcastle, NSW; Rick Pointon, Consumer; Teresa Simpson, Senior Clinician, Psycho-Oncology Social Work Service, Cancer Therapy Centre, Liverpool Hospital, NSW.
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The information on this webpage was adapted from Understanding Head and Neck Cancers - A guide for people with cancer, their families and friends (2021 edition). This webpage was last updated in November 2021.