Overcoming resistance to bromodomain inhibition in MYC driven lymphoma

Project Description

Lymphomas are cancers of the white blood cells. Some of the worst lymphomas are caused by a gene called ‘MYC'. Recent developments have produced a new drug-class that inhibits MYC. These ‘MYC inhibitors' can kill lymphomas but some cells survive and become resistant. Our research will generate and isolate resistant lymphomas and work out how they have developed resistance. This information will then be used to test new drug combinations to prevent resistance happening in patients.

Lay report

Year

2015-2017

Researchers

Dr Jake Shortt, Prof Ricky Johnstone

Funding Body

Cancer Council Research Grant

Institution

Gene Regulation Laboratory, Peter MacCallum Cancer Centre

Funding

$99,268 in 2015, $99,805 in 2016 and $100,000 in 2017

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