Bowel cancer is common. Many people have someone in their family diagnosed with bowel cancer. Multiple family members can have bowel cancer:
If you have a family history of bowel cancer (no matter what your age) it's important to talk with your doctor. Knowing which of your relatives has had bowel cancer and the ages at which they were diagnosed can help your doctor estimate your risk. It may also be helpful for your doctor to know whether there have been any other cancers (apart from bowel cancer) in your family.
If you find out about any new diagnoses of cancer in your family, it's important to discuss this with your doctor as this may change advice to you.
First degree relatives are your mother, father, brothers, sisters and children. Second degree relatives are your grandparents, aunts, uncles, nieces, nephews and grandchildren.
Average risk: This will apply if you have:
Slightly above average: Applies if you have:
Speak to a doctor if you fit into the average risk or slightly above-average risk category for advice about the type of tests needed and at what age.
Moderately increased risk: Some people have an increased chance of bowel cancer because of their family history. This includes people with:
Speak to your doctor if you fit into the moderately increased risk category.
Potentially high risk: A few people may have a potentially higher chance of bowel cancer. These are people with:
Speak to a doctor if you fit into the potentially high-risk category. Doctors can discuss appropriate bowel checks for you and may refer you to a family cancer centre.
This condition runs in families, causing people to develop large numbers of 'adenomatous' or pre-cancerous polyps in the bowel. Polyps are small growths, often on stalks like a mushroom. They vary in size from a tiny pinhead to two centimetres or more.
If FAP is not treated, a bowel cancer will almost always develop in one or more polyps.
FAP is caused by a change in a gene called APC. Our genes carry the instructions that control how our bodies grow, develop and work. APC controls the way the lining of the bowel develops. Everybody has this gene, although only people with a change in the gene (called a mutation) develop FAP. Once this mutation has occurred, it can be passed from parent to child.
If you have a parent with FAP, you have a 50/50 chance of having FAP. If you have a brother or sister with FAP, you may also be at risk. The risk is the same for males and females.
Genetic testing is available for most people at risk of FAP. This can tell you with certainty whether you have the FAP gene. If you have not inherited the gene change, it's very unlikely that you'll develop FAP.
Contact your nearest family cancer centre for more information.
HNPCC is also known as Lynch Syndrome. It's another inherited bowel cancer. People who have HNPCC have a high risk of bowel cancer. Women are also at increased risk of cancer of the uterus (also known as endometrial cancer or cancer of the womb). More rarely, other cancers can occur. People with HNPCC can develop polyps in the bowel, although these occur in fewer numbers than in FAP.
HNPCC is caused by a gene change (mutation) which affects how the gene works. Our genes carry the instructions that control how our bodies grow, develop and function. There are at least 4 genes connected with HNPCC and normally they are involved in preventing cancers. Everybody has these genes, but if a person has a change in one of these genes they have HNPCC. This gene change can be passed on from parent to child. If you have a parent with HNPCC you have a 50/50 chance of inheriting the changed gene. If you're aware of any member of your extended family with HNPCC, you may be at risk and you should contact a family cancer centre.
Having HNPCC doesn't necessarily mean you'll develop cancer. Not all people who carry the gene develop cancer.
Genetic testing is available for some people at risk of HNPCC. For more information contact your nearest family cancer centre.
Depending on which category you fit into, there are tests that can pick up bowel cancers at an early stage before there are any signs. Your doctor will advise which tests are appropriate for you and how often these should be done.
Research shows about 90% of bowel cancer can be cured if picked up at the earliest stage.
Types of tests that might be done include: