Early-onset denotes cancers diagnosed in individuals younger than expected, typically under 50 years of age. In this report, they are defined as cancers diagnosed in Victorians aged 25–49.
Although they represent just 11% of all cancers diagnosed in 2023, early-onset cancers have significant impacts on individuals and society. They often occur during critical life stages, causing psychological, financial, and social challenges, and may require aggressive treatment and long-term follow-up.
In 2023, 4,294 early-onset cancers were diagnosed in Victoria, with females 70% more likely than males to be affected. Breast, thyroid, bowel, and melanoma were the most common cancers in females, while bowel, melanoma, testis, and prostate cancers were most frequent in males. Trends show a global rise in early-onset cancers since the 1990s, with increasing rates in colorectal, kidney, thyroid, and other cancers.
Monitoring early-onset cancers is essential for understanding future healthcare needs, identifying disparities, guiding prevention efforts, and improving outcomes. Upward trends highlights the importance of early detection, public awareness, and tailored health policies to address the unique challenges faced by younger cancer patients.
A snapshot of early onset cancers in Victoria in 2023:
- Early-onset cancers account for 11% of all cancers diagnosed in Victorians in 2023, with females 70% more likely than males to be diagnosed with an early-onset cancer.
- Early-onset cancers accounted for 4% of all cancer deaths in Victorians in 2023.
- Five-year survival after an early-onset cancer is 87% and ten-year survival is 82%.
- Bowel cancer is the most common cancer diagnosed among Victorians aged 25-49 years.
- Breast cancer is the most commonly diagnosed cancer in females aged 25 to 49 years.
- Melanoma incidence has been declining significantly among younger Victorians, with recent data showing a sharper annual decline in females than in males.
- For every 10 males diagnosed with thyroid cancer, there are about 34 females diagnosed.
Survival rates for early-onset cancer are higher than for older Victorians. In females, five-year survival is 88.9% and 10-year survival is 83.6%; in males, five-year survival is 83.3% and 10-year survival is 79.2%. This advantage likely stems from biological factors, better health, and more aggressive initial treatments.
Early-onset bowel cancer
Bowel cancer is the most common cancer in Victorians aged 25–49, with 466 new cases in 2023 (235 females, 231 males), comprising 12% of all bowel cancers in the state. Incidence rates are increasing annually by 2.6% in younger adults, contrasting with declines in older groups.
Early-onset cases are often more advanced at diagnosis, likely due to delayed symptom recognition and differences in tumour biology. Mortality rates for early-onset cases are rising (1.8% annually), unlike declining rates in older groups, but five-year survival remains comparable between age groups.
Early-onset breast cancer
Breast cancer is the most commonly diagnosed cancer among Victorian females aged 25–49, accounting for 1,067 cases in 2023, or 39.8% of early-onset cancers in females. Incidence rates are increasing by 0.6% annually for this age group.
Early-onset breast cancers often present more advanced disease, with higher rates of aggressive subtypes like triple-negative breast cancer. Despite this, mortality rates have declined faster in younger females (-3.2% annually) than in older groups since 1993. Five-year survival for early-onset breast cancer between 2018–2022 was 93.4%, and 10-year survival was 87.1%, comparable to older age groups.
Early-onset melanoma
Melanoma is the third most common early-onset cancer in Victorians, with 396 cases diagnosed in 2023 (220 females, 176 males), representing 12.5% of all melanoma cases. Incidence rates for early-onset melanoma have declined annually by 2.0% since 1997, driven by public health campaigns like SunSmart and reduced UV exposure from tanning solarium bans.
In 2023, 83% of early-onset melanomas were diagnosed at an early stage, and the age-standardised mortality rate was low at 0.5 deaths per 100,000. Five-year survival is high, at 97.7% for females and 96.5% for males, reflecting advances in early diagnosis and treatment options.
Early-onset lung cancer
Lung cancer accounted for 146 early-onset cases in Victoria in 2023, evenly split between females and males, comprising 4.2% of all lung cancer diagnoses. Incidence rates are rising among younger females (0.5% annually) but have stabilised for males.
Mortality rates are declining (-2.2% annually) but remain higher in males. Early-onset cases often involve carcinoid lung cancer, which has better survival rates. Five-year survival is 46.6% for females and 35.0% for males, underscoring the challenges in improving outcomes for younger patients.
Early-onset ovarian cancer and serous cancers of the fallopian tubes
Ovarian cancer and serous carcinomas of the fallopian tube accounted for 81 early-onset cases in Victorian females in 2023, comprising 3% of early-onset cancers in females. Incidence rates for younger females have remained stable, while rates in older age groups have declined.
These cancers often present at an advanced stage due to vague symptoms and lack of routine screening. Five-year survival for early-onset cases is 78.5%, declining to 64.2% at 10 years, significantly higher than survival rates in older age groups.
Early-onset thyroid cancer
Thyroid cancer is the second most common cancer in females aged 25–49 and accounted for 322 early-onset cases in Victoria in 2023 (248 females, 74 males), representing 37% of all thyroid cancer cases. Incidence rates have risen significantly over the past four decades, driven by improved detection through advanced diagnostic techniques and increased awareness.
Risk factors include genetic predisposition and ionising radiation exposure. Early-onset thyroid cancer has an excellent prognosis, with five- and ten-year survival rates exceeding 96% for both sexes, though treatment often leads to lifelong thyroid hormone replacement and other morbidities.
Early-onset testicular cancer
Testicular cancer is the third most common cancer in Victorian males aged 25–49, with 172 early-onset cases in 2023, accounting for 72% of all testicular cancer cases. Incidence rates have risen by 2% annually since 1982 but have declined by 1.6% annually since 2015.
Risk factors include undescended testicles, inguinal hernia, and sedentary lifestyles. Advances in platinum-based chemotherapy and treatment technologies have dramatically improved outcomes, making testicular cancer one of the most survivable cancers, with five-year survival rates now exceeding 90%.