Lead researcher
Prof Ygal Haupt, Dr Shahneen Sandhu
Institution
Sr Peter MacCallum Department of Oncology, The University of Melbourne
Years funded
2015-2017
Prostate cancer (PC) is a major
health issue. Progression to castration resistant disease is highly lethal due
to treatment resistance. We found that, PML, a key suppressor of PC, is
promoted for degradation by the enzyme, E6AP. Increased E6AP expression is
associated with a loss of PML in PC. Here we propose to test the anti-tumour
efficacy of blocking E6AP to restore the ability of PML to selectively kill PC
cells. If successful, this will form a novel treatment for localized and
advanced PC.
Funding Body
Cancer Council Research Grant
Funding
$100,000 per annum