Determining how a novel protein controls cell shape

Lead researcher

A/Prof Helena Richardson

A/Prof Helena Richardson

Institution
La Trobe University

Tumour type:
Lung and pancreatic

Years funded
2017-2019

Project description

We have discovered a new protein and shown how it is important in restraining tumour growth in models of cancer, and how low expression correlates with poor prognosis in lung and pancreatic cancer. In this proposal we will determine the role of this suppressor in regulating cell shape and how it cooperates in cancer progression. 

What are you trying to achieve?

This project will determine how a new protein that we have shown to contribute to cancer progression affects cell shape, tissue structure and communication pathways important for cancer development. The outcomes of this project might reveal a new cancer biomarker and lead to the identification of novel therapeutic approaches to combat particular cancers.

What is your personal motivation?

Caner is an insidious disease affecting a third of Australians, and several of my close family members have been affected by, or died from, cancer.

As a research scientist, trained in molecular and cell biology using model organisms, I believe that understanding the molecular mechanisms by which cancer arises is the most effective means to rapidly and cost-effectively discover new approaches for the diagnosis, prognosis and treatment of cancer.

Project timeline

2017  2018 
2019 

Determine the molecular mechanism by which the protein regulates cell shape.

Determine the signaling pathways affected by the protein.

 
  

Determine the molecular mechanism by which the protein regulates cell shape.

Determine the signaling pathways affected by the protein.

Determine the protein functional interacting network. 

 

Determine the signaling pathways affected by the protein.

Determine the protein functional interacting network. 

"The outcomes of this project might reveal a new cancer biomarker and lead to the identification of novel therapeutic approaches to combat particular cancers."

Collaborators

A/Prof Patrick Humbert, Prof Josef Penninger