Friend or foe? Deciphering the conflicting functions of YAP in breast cancer

Lead researcher

Dr Lan Nguyen

Dr Lan Nguyen

Institution

Monash Biomedicine Discovery Institute, Monash University

Tumour type:

Breast

Years funded

2017-2019

Project description

This project employs an innovative approach that synergises computational and experimental methods to decipher the function of YAP in breast cancer.

This will likely lead to rational ways to classifypatients into groups who may (or may not) benefit from targeted therapy directed at YAP. 

What are you trying to achieve?

This project employs an innovative approach that uses computational and experimental methods to understand how YAP, an important protein involved in breast cancer development, makes specific decisions that lead cancer cells to either grow or die.

Based on this understanding, I will predict individualised therapeutic strategies that provide informed decisions as to when using agents directed at YAP would be useful for patients.

I will then validate these predictions in the laboratory. 

What is your personal motivation?

Cancer is a greatly complex disease and I am strongly driven to untangle such complexity using multi-disciplinary approaches combining computational and experimental methods.

Project timeline

2017  2018 
2019 

    Contruct a predictive model for an integrated molecular network centred on YAP  

 

Decipher the context-specific function of YAP in breast cancer    

Decipher the context-specific function of YAP in breast cancer

Develop network-level biomarkers for YAP directed agents 

"Cancer is a greatly complex disease and I am strongly driven to untangle such complexity using multi-disciplinary approaches combining computational and experimental methods."