Enhancing activation and trafficking of T cells for cancer therapy

Lead researcher

A/Prof Phillip Darcy, A/Prof Michael Kershaw

Cancer Immunology Research, Peter MacCallum Cancer Centre

Years funded

White blood cells from cancer patients can be modified in the laboratory to react against tumours. However the poor trafficking of these cells to the tumour site and the fact that cancer cells can effectively turn off these gene-modified cells has hampered this approach. We propose to fully address these two critical issues using innovative techniques and mouse models that closely recapitulate the human setting. We anticipate that these studies will lead to a more effective therapy for patients.  

Funding Body

Cancer Council Research Grant

Award / Duration

Bruce Ward Grant-in-Aid


$100,000 per annum