Developing a second primary cancer is not uncommon, with second cancers making up 14% of all new cancers. A small number of people develop three or more unrelated primary cancers in their lifetime. Previous research has shown that among people diagnosed with three or more primary tumours (multiple primary cancers), less common tumour types appear more frequently than expected. This analysis will study the genes of people diagnosed with three or more primary tumours to identify new and potentially rare genetic variants that may increase a person’s susceptibility to cancer.
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