Different pain medicines take different amounts of time to work. How long each one takes depends on whether the ingredient that makes the medicine work, known as the active ingredient, is released slowly or immediately. 

• Slow release medicines – also known as sustained release medicines, these release the active ingredient continuously to provide pain control over a longer period of time, often for 12–24 hours. They are used for constant pain and need to be taken as prescribed. This helps keep the amount of medicine in the blood high enough to work well.
• Immediate release medicines – these release the active ingredient fast, usually in less than 30 minutes. They are used for occasional, temporary pain (breakthrough pain) because they work quickly but for a short period of time, often for 4–6 hours.

How quickly different medicines relieve pain also varies greatly from person to person. It depends on how much medicine you take (the dose) and how often you take it (the frequency).

Pain medicines need to be taken as prescribed to control pain. This helps maintain a steady level of medicine in the body. Some people call this 'staying on top of the pain'.

By taking your pain medicine regularly, even if you are not in pain, your pain may come back as mild rather than strong pain. It is important to use the correct pain medicine at the right time for it to work. 

To manage your pain, your health care team may recommend a combination of prescription and non-prescription medicines. You may also consider trying complementary therapies.

• Prescription medicines – medicines that your doctor must authorise you to take and only a pharmacist can give you. Most prescription medicines have two names – a generic name (identifies the chemical compounds in the drug that make it work) and a brand name (created by the pharmaceutical company that made the medicine). The generic name will be on the prescription, but the brand name may appear on the box. A medicine may have more than one brand name if it’s produced by different companies.
• Non-prescription medicines – available without a prescription and can be bought from pharmacies and supermarkets. They include over-the-counter medicines such as mild pain medicines and cold medicines, vitamin supplements and herbal remedies.
• Allied health services – offer therapies, such as physiotherapy, exercises, special equipment and psychological therapies, to help people manage their pain and stay comfortable.
• Complementary therapies – therapies that can be used alongside conventional medical treatments to improve your quality of life and wellbeing.

Pain medicines are taken in several ways, depending on the type of medicine and the form that it is available in. Examples include a tablet or capsule, skin patch, injection, liquid, intravenous infusion and suppository, among others.

There are different ways to remember all the medicines you are taking and help ensure you take the correct dose at the right time. 

You can ask your pharmacist to organise your tablets and capsules into a blister pack (e.g. Webster-pak), which sets out all the doses that need to be taken throughout the week, along with a description of each drug.

A medicines list keeps all the information about your medicines together. You can record what you need to take, what each medicine is for, when to take it, and how much to take. You can:

• create your own list on paper or online
• order a printed NPS MedicineWise list to keep in your wallet or handbag
• download the MedicineWise app from the Apple Store or Google Play onto your smartphone. You can scan the barcode on packaging to add a medicine to the app and set up alarms for taking the medicine. 

Family members, carers and friends sometimes have opinions about the pain relief you’re having. They may feel anxious about you using pain medicines such as opioids, because they are worried you will become addicted.

Let your family know how pain affects what you can do and how you feel, and that keeping the pain under control allows you to remain comfortable and enjoy your time with them. You may want to ask your health care team if they can explain to your family and carers why a particular medicine has been recommended for you.

Many cold and flu pills and other over-the-counter medicines contain paracetamol or anti-inflammatories. These ingredients count towards your total daily dose, and you may need to take a lower dose of the pain medicine.

Medicines for colds, menstrual (period) pain, headaches, and joint or muscle aches often contain a mixture of drugs, including aspirin. People receiving chemotherapy should check with their oncologist before taking aspirin as it increases the risk of internal bleeding. Aspirin may also cause minor cuts to bleed a lot and take longer to stop bleeding.

Over-the-counter medicines for allergies may cause drowsiness, as can some pain medicines. Taking them together can make it dangerous to drive and to operate machinery.

You can search the Database of Adverse Event Notifications (DAEN), created by the Therapeutic Goods Administration (TGA), which includes information about medicines and medical devices that haven’t worked well.

• Ask your doctor or pharmacist for written information about your pain medicines including what they are for, when and how to take them, possible side effects and how to manage them, and possible interactions with other medicines, vitamins or herbal supplements or remedies.
• Take only the prescribed dose. Do not stop taking a medicine or change the dose without talking to your doctor.
• Keep medicines in their original packaging or ask your pharmacist to put the medicines into a labelled blister pack to avoid dangerous mix-ups.
• Store medicines in a safe place that is out of reach of children.
• Write a note or set an alarm on your smartphone to remind yourself when to take your medicines.
• Ask your GP whether a pharmacist could check what medicines you’re taking and that you’re taking them correctly. This is known as a home medicines review.
• Check the expiry dates of medicines. If they are near or past their expiry, see your doctor for a new prescription.
• Take out-of-date medicines or any that you no longer need to the pharmacy for safe disposal.
• Ask your doctor or pharmacist what activities are safe when taking pain medicines (e.g. driving, using machinery).
• Call the Medicines Line on 1300 633 424 for information on medicines.
• Let your health care team know of any side effects. Call the Adverse Medicine Events Line on 1300 134 237 if you suspect you’ve had a reaction to any kind of medicine. If you need urgent assistance, call Triple Zero (000) or go to a hospital emergency department.

• Ask your doctor if you need to change your medicine schedule to allow for time differences and if there are limits on the amount of medicines you can take overseas.
• Check with the consulates or embassies of the countries you’re visiting to make sure your medicine is legal there and if there are restrictions on how much medicine you can take with you.
• Put any medicines you need during the flight (including extra doses in case you are delayed) in your carry-on baggage ready for screening at the airport, and pack the rest in your checked baggage.
• Carry a letter from your doctor listing each medicine, how much you’ll be taking, any equipment you need, and stating that the medicine is for your personal use.
• Keep medicines in their original packaging, which includes the label with your name, so they can be easily identified, and make sure the name on the medicines matches the name on the passport.
• Call the Travelling with PBS Medicines Enquiry Line on 1800 500 147 for more information.