Dr Urmi Dhagat
St Vincent's Institute of Medical Research
This project studies the mechanism by which a protein hormone (interleukin-3) activates abnormal signalling in leukaemic cells. Our findings will allow the development of new approaches to target and disrupt leukaemic cell survival.
We want to find out more about what causes leukaemia and develop a new treatment. This research will have implications for all people diagnosed with this type of cancer.
Interleukin 3 (IL-3) plays an important role in promoting leukaemic cell growth and survival and is often involved in leukaemia relapse. Despite the central role played by IL-3 in blood cancer biology, little is known about how it contributes to cell growth and disease. Our study will use 3D structures of IL-3 to assess how the hormone controls signaling outcomes within the cell.
I was exposed to the stress and anxiety that cancer can bring on a family at a very young age. I've also experienced its impact as an adult when a close friend and mother-of-two passed away last year after being diagnosed with breast cancer at the age of 32. She went through several chemotherapy sessions but none of them were effective in her case.
It's for these reasons that I am motivated and proud to be working in the field of cancer research.
Insights into affinity conversion using molecular dynamics.
Establish a structural basis for the differential signaling outcomes.
Distinguish signaling outcomes.
Use antibodies as tools to study receptor function.
"I truly believe that investment in scientific research can ensure a better future for cancer patients."
Dr Sophie Broughton, Prof Michael Parker, A/Prof Louise Purton
P: +61 3 9514 6100
F: +61 3 9514 6800
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