HealthIron: epidemiology of hereditary haemochromatosis

Investigators

Gertig D, Allen K, Anderson G, Bahlo M, Bassett M, Delatycki M, Du Sart D, English D, Forrest S, Giles G, Hodge A, Hopper J, Mclaren C, Olynyk J, Powell L, Southey M, Vulpe C

Objectives

  • To determine what environmental risk factors modify hereditary haemochromatosis.
  • To identify genetic variants which modify the haemochromatosis phenotype.

Publications

Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ, McLaren CE, Bahlo M, Nisselle AE, Vulpe CD, Anderson GJ, Southey MC, Giles GG, English DR, Hopper JL, Olynyk JK, Powell LW, Gertig DM. Iron-overload-related disease in hfe hereditary hemochromatosis (editorial). N Engl J Med. 2008;358:221-230

Constantine CC, Gurrin LC, McLaren CE, Bahlo M, Anderson GJ, Vulpe CD, Forrest SM, Allen KJ, Gertig DM. Snp selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis. BMC Med Genet. 2008;9:18

Gurrin LC, Osborne NJ, Constantine CC, McLaren CE, English DR, Gertig DM, Delatycki MB, Southey MC, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Allen KJ. The natural history of serum iron indices for hfe c282y homozygosity associated with hereditary hemochromatosis. Gastroenterology. 2008;135:1945-1952

Constantine CC, Anderson GJ, Vulpe CD, McLaren CE, Bahlo M, Yeap HL, Gertig DM, Osborne NJ, Bertalli NA, Beckman KB, Chen V, Matak P, McKie AT, Delatycki MB, Olynyk JK, English DR, Southey MC, Giles GG, Hopper JL, Allen KJ, Gurrin LC. A novel association between a snp in cybrd1 and serum ferritin levels in a cohort study of hfe hereditary haemochromatosis. Br J Haematol. 2009;147:140-149

Gurrin LC, Bertalli NA, Dalton GW, Osborne NJ, Constantine CC, McLaren CE, English DR, Gertig DM, Delatycki MB, Nicoll AJ, Southey MC, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Allen KJ. Hfe c282y/h63d compound heterozygotes are at low risk of hemochromatosis-related morbidity. Hepatology. 2009;50:94-101

Allen KJ, Bertalli NA, Osborne NJ, Constantine CC, Delatycki MB, Nisselle AE, Nicoll AJ, Gertig DM, McLaren CE, Giles GG, Hopper JL, Anderson GJ, Olynyk JK, Powell LW, Gurrin LC. Hfe cys282tyr homozygotes with serum ferritin concentrations below 1000 microg/l are at low risk of hemochromatosis. Hepatology. 2010;52:925-933

Osborne NJ, Gurrin LC, Allen KJ, Constantine CC, Delatycki MB, McLaren CE, Gertig DM, Anderson GJ, Southey MC, Olynyk JK, Powell LW, Hopper JL, Giles GG, English DR. Hfe c282y homozygotes are at increased risk of breast and colorectal cancer. Hepatology. 2010;51:1311-1318

Bertalli NA, Allen KJ, McLaren CE, Turkovic L, Osborne NJ, Constantine CC, Delatycki MB, English DR, Giles GG, Hopper JL, Anderson GJ, Olynyk JK, Powell LW, Gurrin LC. A comparison of self-reported and record-linked blood donation history in an australian cohort. Transfusion. 2011;51:2189-2198

Wang Y, Gurrin LC, Wluka AE, Bertalli NA, Osborne NJ, Delatycki MB, Giles GG, English DR, Hopper JL, Simpson JA, Graves S, Allen KJ, Cicuttini FM. Hfe c282y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis. Semin Arthritis Rheum. 2011 (in print)

Updated: 05 Jun, 2013