Risk factors for age-related macular degeneration (AMD)

Investigators

Luba Robman*, Robyn Guymer*, Graham Giles, Dallas English (* External collaborators)

Objectives

  • To estimate the prevalence and severity of age related macular degeneration in the Melbourne Collaborative Cohort Study.
  • To evaluate the association of age related macular degeneration with dietary intake of carotenoids, lutein and zeaxanthin, family history, smoking based on baseline and follow up data.
  • To determine apoE genotype of the participants and estimate its effect on age-related macular degeneration prevalence.
  • To assess epidemiological interaction between dietary carotenoids and apoE genotype as risk factors for AMD and to estimate whether the course of age-related macular degeneration in people at higher risk could be modified through dietary intake of the carotenoids lutein and zeaxanthin.

Publications

Robman L, Vu H, Hodge A, McCarty CA, Taylor HR. Dietary lutein and zeaxanthin: Authors' response. Br J Ophthalmol. 2006;90:1211-1212

Vu HT, Robman L, Hodge A, McCarty CA, Taylor HR. Lutein and zeaxanthin and the risk of cataract: The melbourne visual impairment project. Invest Ophthalmol Vis Sci. 2006;47:3783-3786

Vu HT, Robman L, McCarty CA, Taylor HR, Hodge A. Does dietary lutein and zeaxanthin increase the risk of age related macular degeneration? The melbourne visual impairment project. Br J Ophthalmol. 2006;90:389-390

Aung KZ, Robman L, Chong EW, English DR, Giles GG, Guymer RH. Non-mydriatic digital macular photography: How good is the second eye photograph? Ophthalmic Epidemiol. 2009;16:254-261

Chong EW, Robman LD, Simpson JA, Hodge AM, Aung KZ, Dolphin TK, English DR, Giles GG, Guymer RH. Fat consumption and its association with age-related macular degeneration. Arch Ophthalmol. 2009;127:674-680

Chong EW, Simpson JA, Robman LD, Hodge AM, Aung KZ, English DR, Giles GG, Guymer RH. Red meat and chicken consumption and its association with age-related macular degeneration. Am J Epidemiol. 2009;169:867-876

Adams MK, Simpson JA, Aung KZ, Makeyeva GA, Giles GG, English DR, Hopper J, Guymer RH, Baird PN, Robman LD. Abdominal obesity and age-related macular degeneration. Am J Epidemiol. 2011;173:1246-1255

Adams MK, Simpson JA, Richardson AJ, English DR, Aung KZ, Makeyeva GA, Guymer RH, Giles GG, Hopper J, Robman LD, Baird PN. Apolipoprotein e gene associations in age-related macular degeneration: The melbourne collaborative cohort study. Am J Epidemiol. 2012;175:511-518

Updated: 02 Oct, 2012