Colorectal Cancer
Ait Ouakrim D, Dashti SG, Chau R, Buchanan DD, Clendenning M, Rosty C, Winship IM, Young JP, Giles GG, Leggett B, Macrae FA, Ahnen DJ, Casey G, Gallinger S, Haile RW, Le Marchand L, Thibodeau SN, Lindor NM, Newcomb PA, Potter JD, Baron JA, Hopper JL, Jenkins MA, Win AK. Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome. J Natl Cancer Inst. 2015;107(9):pii: djv170
Hodge A, Williamson EJ, Bassett JK, MacInnis RJ, Giles GG, English DR. Dietary and biomarker estimates of fatty acids and risk of colorectal cancer. Int J Cancer. 2015;137(5):1224-34
Karahalios A, English DR, Simpson JA. Weight Change and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis. Am J Epidemiol. 2015;181(11):832-45
Lemire M, Qu C, Loo LW, Zaidi SH, Wang H, Berndt SI, Bezieau S, Brenner H, Campbell PT, Chan AT, Chang-Claude J, Du M, Edlund CK, Gallinger S, Haile RW, Harrison TA, Hoffmeister M, Hopper JL, Hou L, Hsu L, Jacobs EJ, Jenkins MA, Jeon J, Kury S, Li L, Lindor NM, Newcomb PA, Potter JD, Rennert G, Rudolph A, Schoen RE, Schumacher FR, Seminara D, Severi G, Slattery ML, White E, Woods MO, Cotterchio M, Le Marchand L, Casey G, Gruber SB, Peters U, Hudson TJ. A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1. Hum Genet. 2015;134(11-12):1249-62
Schumacher FR, Schmit SL, Jiao S, et al. Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nature communications. 2015;6:7138
Win AK, Buchanan DD, Rosty C, MacInnis RJ, Dowty JG, Dite GS, Giles GG, Southey MC, Young JP, Clendenning M, Walsh MD, Walters RJ, Boussioutas A, Smyrk TC, Thibodeau SN, Baron JA, Potter JD, Newcomb PA, Le Marchand L, Haile RW, Gallinger S, Lindor NM, Hopper JL, Ahnen DJ, Jenkins MA. Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives. Gut. 2015;64:101-110
Win AK, Clendenning M, Crawford W, Rosty C, Preston SG, Southey MC, Parry S, Giles GG, Macrae FA, Winship IM, Baron JA, Hopper JL, Jenkins MA, Buchanan DD. Genetic variants within the hTERT gene and the risk of colorectal cancer in Lynch syndrome. Genes & cancer. 2015;6:445-451
Prostate Cancer
Al Olama AA, Dadaev T, Hazelett DJ, et al. Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans. Hum Mol Genet. 2015;24(19):5589-602
Al Olama AA, Benlloch S, Antoniou AC, Giles GG, et al. Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci. Cancer Epidemiol Biomarkers Prev. 2015;24(7):1121-9
Bolton D, Ong K, Giles G, Lawrentschuk N, Severi G, Papa NP, Troy A, Woo HH, Millar J, Royce P. A Whole of Population, Multi-user Series of HIFU for Management of Localised Prostate Cancer: Outcomes and Implications. Journal of endourology/Endourological Society. 2015;29(7):844-9
Bolton D, Papa N, Ta A, Millar J, Davidson AJ, Pedersen J, Syme R, Patel MI, Giles GG. Predictors of Prostate Cancer Specific Mortality after Radical Prostatectomy: 10 year oncologic outcomes from the Victorian Radical Prostatectomy Registry. BJU Int. 2015;116 Suppl 3:66-72
Davies NM, Gaunt TR, Lewis SJ, et al. The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium. Cancer Causes Control. 2015;26(11):1603-16
Key TJ, Appleby PN, Travis RC, et al, Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. Am J Clin Nutr. 2015;102(5):1142-57
Rynkiewicz NK, Fedele CG, Chiam K, Gupta R, Kench JG, Ooms LM, McLean CA, Giles GG, Horvath LG, Mitchell CA. INPP4B is highly expressed in prostate intermediate cells and its loss of expression in prostate carcinoma predicts for recurrence and poor long term survival. Prostate. 2015;75(1):92-102
Stegeman S, Amankwah E, Klein K, O'Mara TA, Kim D, Lin HY, Permuth-Wey J, Sellers TA, Srinivasan S, Eeles R, Easton D, Kote-Jarai Z, Amin Al Olama A, Benlloch S, Muir K, Giles GG, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Pharoah P, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Kaneva R, Teixeira MR, Consortium P, BioResource AP, Spurdle AB, Clements JA, Park JY, Batra J. A large scale analysis of genetic variants within putative miRNA binding sites in prostate cancer. Cancer discovery. 2015;5(4):368-79
Szulkin R, Whitington T, Eklund M, et al. Prediction of individual genetic risk to prostate cancer using a polygenic score. Prostate. 2015;75(13):1467-74
Szulkin R, Karlsson R, Whitington T, et al. Genome-wide association study of prostate cancer-specific survival. Cancer Epidemiol Biomarkers Prev. 2015;24(11):1796-800
Ta AD, Papa NP, Lawrentschuk N, Millar JL, Syme R, Giles GG, Bolton DM. Increased prostate cancer specific mortality following radical prostatectomy in men presenting with voiding symptoms-A whole of population study. Prostate international. 2015;3:75-79
Endometrial Cancer
Carvajal-Carmona LG, O'Mara TA, Painter JN, et al. Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk. Hum Genet. 2015;134(2):231-245
O'Mara TA, Glubb DM, Painter JN, et al. Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer. Endocrine-related cancer. 2015;22(5):851-861
Ovarian Cancer
Amankwah EK, Lin HY, Tyrer JP, et al. Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk. Genet Epidemiol. 2015;39(8):689-97
Besevic J, Gunter MJ, Fortner RT, et al. Reproductive factors and epithelial ovarian cancer survival in the EPIC cohort study. Br J Cancer. 2015;113(11):1622-3
Chornokur G, Lin HY, Tyrer JP, et al. Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk. PLoS One. 2015;10:e0128106
Jim HS, Lin HY, Tyrer JP, et al. Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC). Journal of genetics and genome research. 2015;2(2)
Kamieniak MM, Rico D, Milne RL, et al. Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients. Molecular oncology. 2015;9:422-436
Kar SP, Tyrer JP, Li Q, et al. Network-based integration of GWAS and gene expression identifies a HOX-centric network associated with serous ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 2015;24(10):1574-84
Kuchenbaecker KB, Ramus SJ, Tyrer J, et al. Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet. 2015;47(2):164-71
Lawrenson K, Iversen ES, Tyrer J, et al. Common Variants at the CHEK2 Gene Locus and Risk of Epithelial Ovarian Cancer. Carcinogenesis. 2015;36(11):1341-53
Lawrenson K, Li Q, Kar S, et al. Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer. Nature communications. 2015;6:8234
Lee AW, Tyrer JP, Doherty JA, et al. Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study. Gynecol Oncol. 2015;136(3):542-8
Lu Y, Cuellar G, Painter JN, et al. Shared genetics underlying epidemiological association between endometriosis and ovarian cancer. Hum Mol Genet. 2015;24(20):5955-64
Obon-Santacana M, Peeters PH, Freisling H, et al. Dietary intake of acrylamide and epithelial ovarian cancer risk in the european prospective investigation into cancer and nutrition (EPIC) cohort. Cancer Epidemiol Biomarkers Prev. 2015;24:291-297
Ose J, Fortner RT, Schock H, Peeters PH, et al. Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort. Br J Cancer. 2015;112:162-166
Ose J, Schock H, Tjonneland A, Hansen L, Overvad K, Dossus L, Clavel-Chapelon F, Baglietto L, Boeing H, Trichopolou A, Benetou V, Lagiou P, Masala G, Tagliabue G, Tumino R, Sacerdote C, Mattiello A, Bueno-de-Mesquita HB, Peeters PH, Onland-Moret NC, Weiderpass E, Gram IT, Sanchez S, Obon-Santacana M, Sanchez-Perez MJ, Larranaga N, Castano JM, Ardanaz E, Brandstedt J, Lundin E, Idahl A, Travis RC, Khaw KT, Rinaldi S, Romieu I, Merritt MA, Gunter MJ, Riboli E, Kaaks R, Fortner RT. Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort. Cancer Epidemiol Biomarkers Prev. 2015;24(6):951-61
Ovarian Cancer Association Consortium; Australian Cancer Study; Australian Ovarian Cancer Study Group. Genome-wide significant risk associations for mucinous ovarian carcinoma. Nat Genet. 2015;47(8):888-97
Multiple Cancers
Cheng TH, Thompson D, Painter J, et al. Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Scientific reports. 2015;5:17369
Malham GM, Giles GG, Milne RL, Blecher CM, Brazenor GA. Bone Morphogenetic Proteins in Spinal Surgery: What Is the Fusion Rate and Do They Cause Cancer? Spine. 2015;40:1737-1742
Meeks HD, Song H, Michailidou K, et al. BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers . J Natl Cancer Inst. 2015;108(2): pii: djv315
Painter JN, O'Mara TA, Batra J, et al. Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. Hum Mol Genet. 2015;24(5):1478-92
Pandeya N, Wilson LF, Bain CJ, Martin KL, Webb PM, Whiteman DC. Cancers in Australia in 2010 attributable to tobacco smoke. Aust N Z J Public Health. 2015;39:464-470
Sampson JN, Wheeler WA, Yeager M, et al. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types. J Natl Cancer Inst. 2015;107(12)
Other Cancers
Arem H, Yu K, Xiong X, Moy K, et al. Vitamin D metabolic pathway genes and pancreatic cancer risk. PLoS One. 2015;10:e0117574
Gaudet MM, Kitahara CM, Newton CC, et al. Anthropometry and head and neck cancer:a pooled analysis of cohort data. Int J Epidemiol. 2015;44(2):673-81
Genkinger JM, Kitahara CM, Bernstein L, et al. Central Adiposity, Obesity During Early Adulthood, and Pancreatic Cancer Mortality in a Pooled Analysis of Cohort Studies. Ann Oncol. 2015;26(11):2257-66
Goossens ME, Brinkman M, Zeegers MP, Buntinx F. RE: "Is the Inverse Association Between Selenium and Bladder Cancer Due to Confounding by Smoking? . Am J Epidemiol. 2015;182(10):894
Harding J, Sooriyakumaran M, Anstey KJ, Adams R, Balkau B, Briffa T, Davis TM, Davis WA, Dobson A, Giles GG, Grant J, Knuiman M, Luszcz M, Mitchell P, Pasco JA, Reid C, Simmons D, Simons L, Tonkin A, Woodward M, Shaw JE, Magliano DJ. The metabolic syndrome and cancer: Is the metabolic syndrome useful for predicting cancer risk above and beyond its individual components? Diabetes & metabolism. 2015;41(6):463-9
Hussain SM, Cicuttini FM, Bell RJ, Robinson PJ, Davis SR, Giles GG, Graves S, Milne RL, Wang Y. Reply: Comment on Incidence of total knee and hip replacement for osteoarthritis in relation to circulating sex steroid hormone concentrations in women. Arthritis & rheumatology (Hoboken, N.J.). 2015;67(1):315-6
Jayasekara H, MacInnis RJ, Hodge AM, Hopper JL, Giles GG, Room R, English DR. Lifetime alcohol consumption and upper aero-digestive tract cancer risk in the Melbourne Collaborative Cohort Study. Cancer Causes Control. 2015;26:297-301
Law MH, Bishop DT, Lee JE, et al. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nat Genet. 2015;47(9):987-95
Sultana F, Gertig DM, Wrede CD, English DR, Simpson JA, Drennan KT, Brotherton JM, Phillips G, Heley S, Castle PE, Saville M. A pilot study to compare dry cervical sample collection with standard practice of wet cervical samples for human papillomavirus testing. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 2015;69:210-213
Sultana F, Mullins R, Murphy M, English DR, Simpson JA, Drennan KT, Heley S, Wrede CD, Brotherton JM, Saville M, Gertig DM. Women’s views on human papillomavirus self-sampling: focus groups to assess acceptability, invitation letters and a test kit in the Australian setting. Sexual health. 2015;12(4):279-86
Vijai J, Wang Z, Berndt SI, et al. A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Nature communications. 2015;6
Wang Z, Rajaraman P, Melin BS, et al. Further confirmation of germline glioma risk variant rs78378222 in TP53 and its implication in tumor tissues via integrative analysis of TCGA data. Hum Mutat. 2015;36(7):684-8
Other Conditions
Chong EW, Wang Y, Robman LD, Aung KZ, Makeyeva GA, Giles GG, Graves S, Cicuttini FM, Guymer RH. Age Related Macular Degeneration and Total Hip Replacement Due to Osteoarthritis or Fracture: Melbourne Collaborative Cohort Study. PLoS One. 2015;10(9):e0137322
Cust AE, Pickles KM, Goumas C, Vu T, Schmid H, Nagore E, Kelly J, Aitken JF, Giles GG, Hopper JL, Jenkins MA, Mann GJ. Accuracy of self-reported nevus and pigmentation phenotype compared to clinical assessment in a population-based study of young Australian adults. Cancer Epidemiol Biomarkers Prev. 2015;24(4):736-43
Guida F, Sandanger TM, Castagne R, Campanella G, Polidoro S, Palli D, Krogh V, Tumino R, Sacerdote C, Panico S, Severi G, Kyrtopoulos SA, Georgiadis P, Vermeulen RC, Lund E, Vineis P, Chadeau-Hyam M. Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation. Hum Mol Genet. 2015;24:2349-2359
Hadgraft NT, Lynch BM, Clark BK, Healy GN, Owen N, Dunstan DW. Excessive sitting at work and at home: Correlates of occupational sitting and TV viewing time in working adults. BMC Public Health. 2015;15:899
Hussain SM, Cicuttini FM, Bell RJ, Robinson PJ, Davis SR, Giles GG, Graves S, Milne RL, Wang Y. Reply: Comment on Incidence of total knee and hip replacement for osteoarthritis in relation to circulating sex steroid hormone concentrations in women. Arthritis & rheumatology (Hoboken, N.J.). 2015;67:315-316
Jayasekara H, MacInnis RJ, Hodge AM, Hopper JL, Giles GG, Room R, English DR. Alcohol consumption for different periods in life, intake pattern over time and all-cause mortality. Journal of public health. 201537(4):625-33
Khan B, Nowson CA, Daly RM, English DR, Hodge AM, Giles GG, Ebeling PR. Higher Dietary Calcium Intakes are Associated With Reduced Risks of Fractures, Cardiovascular Events and Mortality: A Prospective Cohort Study of Older Men and Women. J Bone Miner Res. 2015;30(10):1758-66
Khor RC, Bressel M, Tedesco J, Tai KH, Ball DL, Duchesne GM, Farrugia H, Yip WK, Foroudi F. Tolerability and outcomes of curative radiotherapy in patients aged 85 or more years. Med J Aust. 2015;202:153-155
Pereira RA, Hodge A. Food insecurity: a critical public health nutrition concern. Public Health Nutr. 2015;18:2893-2894
Petersen KS, Smith JM, Clifton PM, Keogh JB. Dietary intake in adults with type 1 and type 2 diabetes: validation of the Dietary Questionnaire for Epidemiological Studies version 2 FFQ against a 3-d weighed food record and 24-h urinalysis. The British journal of nutrition. 2015:114(12):2056-63
Robman LD, Islam FM, Chong EW, Adams MK, Simpson JA, Aung KZ, Makeyeva GA, Hopper JL, English DR, Giles GG, Baird PN, Guymer RH. Age-related macular degeneration in ethnically diverse australia: melbourne collaborative cohort study. Ophthalmic Epidemiol. 2015;22(2):75-84
Shang X, Sanders KM, Scott D, Khan B, Hodge A, Khan N, English DR, Giles GG, Ebeling PR. Dietary alpha-Linolenic Acid and Total omega-3 Fatty Acids Are Inversely Associated with Abdominal Aortic Calcification in Older Women, but Not in Older Men. The Journal of nutrition. 2015;145(8):1778-86
Teichtahl AJ, Smith S, Wang Y, Wluka AE, R OS, Giles GG, Cicuttini FM. Occupational risk factors for hip osteoarthritis are associated with early hip structural abnormalities: a 3.0T magnetic resonance imaging study of community-based adults. Arthritis Res Ther. 2015;17:19
Teichtahl AJ, Wang Y, Smith S, Wluka AE, Urquhart D, Giles GG, Hussain SM, Cicuttini FM. Early cartilage abnormalities at the hip are associated with obesity and body composition measures - A 3.0T MRI community-based study. Arthritis Res Ther. 2015;17:107
Teichtahl AJ, Wang Y, Smith S, Wluka AE, Zhu M, Urquhart D, Giles GG, O'Sullivan R, Cicuttini FM. Bone geometry of the hip is associated with obesity and early structural damage - a 3.0T magnetic resonance imaging study of community-based adults. Arthritis Res Ther. 2015;17:112
Teichtahl AJ, Wulidasari E, Brady SR, Wang Y, Wluka AE, Ding C, Giles GG, Cicuttini FM. A large infrapatellar fat pad protects against knee pain and lateral tibial cartilage volume loss. Arthritis Res Ther. 2015;17:318
Wluka AE, Teichtahl AJ, Maulana R, Liu BM, Wang Y, Giles GG, O'Sullivan R, Findlay D, Cicuttini FM. Bone marrow lesions can be subtyped into groups with different clinical outcomes using two magnetic resonance imaging (MRI) sequences. Arthritis Res Ther. 2015;17:270
Woodward M, Peters SA, Batty GD, Ueshima H, Woo J, Giles GG, Barzi F, Ho SC, Huxley RR, Arima H, Fang X, Dobson A, Lam TH, Vathesatogkit P, Asia Pacific Cohort Studies C. Socioeconomic status in relation to cardiovascular disease and cause-specific mortality: a comparison of Asian and Australasian populations in a pooled analysis. BMJ open. 2015;5:e006408
Zaloumis SG, Allen KJ, Bertalli NA, Turkovic L, Delatycki MB, Nicoll AJ, McLaren CE, English DR, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Gurrin LC, HealthIron Study I. Natural history of HFE simple heterozygosity for C282Y and H63D: A prospective 12-year study. J Gastroenterol Hepatol. 2015;30:719-725
Scientific Methods
Clark BK, Lynch BM, Winkler EA, Gardiner PA, Healy GN, Dunstan DW, Owen N. Validity of a multi-context sitting questionnaire across demographically diverse population groups: AusDiab3. The international journal of behavioral nutrition and physical activity. 2015;12:148
Dugue PA, English DR, MacInnis RJ, Joo JE, Jung CH, Milne RL. The repeatability of DNA methylation measures may also affect the power of epigenome-wide association studies. Int J Epidemiol. 2015;44:1460-1461
Li S, Wong EM, Joo JE, Jung CH, Chung J, Apicella C, Stone J, Dite GS, Giles GG, Southey MC, Hopper JL. Genetic and Environmental Causes of Variation in the Difference Between Biological Age Based on DNA Methylation and Chronological Age for Middle-Aged Women. Twin research and human genetics : the official journal of the International Society for Twin Studies. 2015:1-7
Machiela MJ, Zhou W, Sampson JN, et al. Characterization of large structural genetic mosaicism in human autosomes. Am J Hum Genet. 2015;96:487-497
Nguyen-Dumont T, Mahmoodi M, Hammet F, Tran T, Tsimiklis H, Giles G, Hopper J, Registry ABCF, Southey M, Park D. Hi-Plex targeted sequencing is effective using DNA derived from archival dried blood spots. Analytical biochemistry. 2015;470:48-51
Nguyen-Dumont T, Hammet F, Mahmoodi M, Pope BJ, Giles GG, Hopper GG, Southey MC, Park DJ. Abridged adapter primers increase the target scope of Hi-Plex. BioTechniques. 2015;58:33-36
Ransom EK, Lynch BM, Vallance JK, Boyle T. Offering personalized health behavior feedback did not increase response rate: a randomized controlled trial. J Clin Epidemiol. 2015;68(11):1383-4
Wong EM, Joo JE, McLean CA, Baglietto L, English DR, Severi G, Hopper JL, Milne RL, FitzGerald LM, Giles GG, Southey MC. Tools for translational epigenetic studies involving formalin-fixed paraffin-embedded human tissue: applying the Infinium HumanMethyation450 Beadchip assay to large population-based studies. BMC research notes. 2015;8:543