This project explores the role of a group of molecules in controlling the development of cancers - particularly cancers of white blood cells such as leukaemia. One day these molecules may be potential targets for new therapies to treat cancer.
This grant studies a family of proteins that are known as tetraspanins. Tetraspanins are found on the surface of the white blood cells that comprise our immune systems. Genetic engineering has created mice that are incapable of producing certain tetraspanin proteins: CD37 and TSSC6.
Analyses of the immune system of the CD37 and TSS6-deficient mice suggests that tetraspanins are molecules that might be important in preventing cancer.
There are 2 ways that tetraspanins might prevent cancer:
A/Prof Mark Wright
Cancer Council Research Grant
$96,093 in 2009, $98,706 in 2010, $100,000 in 2011