Structural Studies of Cancer Proteins

Project Description

Over-production of pro-survival Bcl-2 proteins is not only a molecular mechanism behind many cancers but confers resistance to treatment by preventing their natural programmed death.

We will explore the molecular structures of the Bcl-2 proteins and anticipate designing drugs that directly inhibit pro-survival Bcl-2 proteins letting loose the natural cell death processes to kill cancer cells selectively.

Annual Lay Report: Structural Studies of Cancer Proteins

Year

2009-2011

Researchers

Dr Mark Hinds, Dr Catherine Day

Institution

Walter & Eliza Hall Institute of Medical Research

Funding

$100,000 per annum

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