The role of necroptosis in tumour suppression & the response of malignant tumour cells to anti-cancer therapy

Project Description

Programmed cell death plays critical roles in development and cell-turnover in the adult. Defects in this process can cause cancer. We will use genetic and biochemical approaches to define the individual roles of necroptosis, a newly described cell death process, and those overlapping with apoptosis in normal development and cell-turnover as well as in cancer.

The objective of this work is to identify potential targets for therapeutic intervention in cancer.

Lay report (Final)

Year

2013-2015

Researchers

Prof Andreas Strasser, Dr Wendy Cook

Funding Body

Cancer Council Victoria Research Grant

Institution

Walter and Eliza Hall Institute of Medical Research

Funding

$99,730 pa for three years

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