How does PTHrP protect cells against DNA damage, but increases cell death?

Project Description

The project explores the role of one protein commonly expressed by breast cancers, that promotes these tumours to grow in bone. We've identified that this same molecule makes these cells more susceptible to a novel anti-cancer agent.

We wish to explore how this protein sensitises cells to anticancer treatment, such that we can improve more effective cancer targeting and treatment.

How does PTHrP protect cells against DNA damage, but increases cell death?

Year

2008

Researchers

A/Prof Matthew Gillespie

Institution

St Vincent's Institute of Medical Research and Prince Henry's Institute of Medical Research

Funding

$100,000

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