The role of spatial cell organisation in cancer
Cell polarity is the property of cells to be spacially oriented in a tissue or organ. Loss of cell polarity is a hallmark of cancer and is associated with more aggressive tumours. In this grant, we propose experiments to understand a new family of proteins that act on cell polarity and proliferation to prevent cancer. We will study how the protein hScrib regulates the behaviour of breast cancer cells and assess whether alterations in hScrib are important for cancer development.
Dr Patrick Humbert, Dr Sarah Russell & Dr Helena Richardson