SCL and Lmo2 are two proteins which cause leukaemia. It is thought that they must bind to each other to do so. To test this, we will cause leukaemia in mice using Lmo2, then remove SCL and observe whether the leukaemia is cured. We will then examine which parts of the SCL protein are needed to bind to Lmo2 and cause leukaemia. This will identify regions that can be targets for anti-leukaemic drugs.
Analysis of the interaction of the T-cell oncoproteins Sc1 and Lmo2 as a therapeutic target for T-cell acute lymphoblastic leukaemia.
Dr Matthew McCormack, Dr Stephen Jane , Dr David Curtis
Cancer Council Research Grant
Royal Melbourne Hospital
Research Grant: 2005-2007