Discovery of drugs to promote the suicide of cancer cells

Project Description

The failure of cells to execute a normal death program is at the heart of many tumours. An important family of proteins, the Bcl-2 family, plays a central regulatory role in determining the commitment of a cell to the death program. Our interests are in determining the three-dimensional structures of these proteins in association with their various interacting partners, and to use the information to discover new drugs for treating cancers in which the death machinery is dysfunctional.

Year

2005, 2006

Researchers

Professor Peter Colman

Institution

Structural Biology Division, Walter and Eliza Hall Institute of Medical Research

Award / Duration

Sir Edward Dunlop Cancer Research Fellowship (2006)

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