A recent discovery was made that genetic variation in Nod2 is associated with susceptibility to Crohn's disease. Nod2 and its homologue, Nod1, are members of a growing family of cytosolic factors related to the apoptosis regulator Apaf-1. Nod1 and Nod2 confer responsiveness to lipopolysaccharides and interact with a mediator of NF-kappaB activation. Nod1 and Nod2 and related Nods appear to regulate the host response to pathogens, a process that may be faulty in certain inflammatory diseases.
Dr Bob Anderson
Walter and Eliza Hall Institute of Medical Research
Victorian Lions Fellowship
$20,000 per annum