Elucidating mechanisms of resistance to therapeutic inhibition of RNA polymerase 1 transcription

Project Description

We have developed the first inhibitor, showing potential for potency in human blood malignancies, of a key step in the process of cell growth that is critical to cancer cell survival. This project aims to advance these studies by understanding how cancer can relapse under this therapy and thus provide better outcomes for patients.

Year

2016-2018

Researchers

Dr Gretchen Poortinga, Prof Grant McArthur, Prof Ross Hannan

Funding Body

Cancer Council Research Grant

Institution

Peter MacCallum Cancer Centre, Division of Research

Funding

$99,483 pa 2016 and 2017, $99,023 in 2018

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