Identifying drug targets for childhood leukaemia

Project Description

SCL and Lmo2 are two proteins which cause leukaemia. It is thought that they must bind to each other to do so. To test this, we will cause leukaemia in mice using Lmo2, then remove SCL and observe whether the leukaemia is cured. We will then examine which parts of the SCL protein are needed to bind to Lmo2 and cause leukaemia. This will identify regions that can be targets for anti-leukaemic drugs.

Identifying drug targets for childhood leukaemia

Year

2005-2007

Researchers

Dr Matthew McCormack, Dr Stephen Jane & Dr David Curtis

Institution

Royal Melbourne Hospital

Award / Duration

Duration: 2005-2007

Funding

$70,000 per annum for 3 years

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