SCL and Lmo2 are two proteins which cause leukaemia. It is thought that they must bind to each other to do so. To test this, we will cause leukaemia in mice using Lmo2, then remove SCL and observe whether the leukaemia is cured. We will then examine which parts of the SCL protein are needed to bind to Lmo2 and cause leukaemia. This will identify regions that can be targets for anti-leukaemic drugs.
Dr Matthew McCormack, Dr Stephen Jane & Dr David Curtis
Royal Melbourne Hospital
$70,000 per annum for 3 years