Are direct apoptosis inducers less mutagenic than chemotherapy drugs?

Project Description

Some new classes of anti-cancer drugs, which are currently being developed and evaluated, directly activate self-destruction pathways within tumour cells, rather than indirectly killing cancer cells via damaging their DNA.

This project explores the exciting possibility that these new agents may be less likely than DNA-damaging chemotherapy or radiotherapy to trigger development of subsequent cancers in patients cured of their original malignancy.

Lay Report - Final

Are direct apoptosis inducers less mutagenic than chemotherapy drugs?

Year

2012-2014

Researchers

Dr Christine Hawkins, A/Prof David Curtis, Dr Elizabeth Algar

Funding Body

Cancer Council Research Grant

Institution

La Trobe University

Funding

$98,725 pa (2012 & 2013), $100,000 (2014)

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