Enhancing activation and trafficking of T cells for cancer therapy

Project Description

White blood cells from cancer patients can be modified in the laboratory to react against tumours. However the poor trafficking of these cells to the tumour site and the fact that cancer cells can effectively turn off these gene-modified cells has hampered this approach. We propose to fully address these two critical issues using innovative techniques and mouse models that closely recapitulate the human setting. We anticipate that these studies will lead to a more effective therapy for patients.

Lay report:




A/Prof Phillip Darcy, A/Prof Michael Kershaw

Funding Body

Cancer Council Research Grant


Cancer Immunoloyg Research, Peter MacCallum Cancer Centre

Award / Duration

Bruce Ward Grant-in-Aid


$100,000 per annum