LRH-1: a novel driver of breast cancer proliferation

Project Description

New therapeutic targets for breast cancer are urgently required. This application focuses on a protein known as LRH-1, which we have previously shown to mediate oestrogen production in breast tissues. We will show that LRH-1 stimulates breast cancer proliferation in animal and preclinical models, and demonstrate the utility of blocking LHR-1 function, using novel inhibitors, as breast cancer therapy.nuclear receptors, endocrinology, cell proliferation, transgenic mouse, mammary gland cancer.

Lay Report:

Year

2015-2017

Researchers

Dr Colin Clyne, Dr Ashwini Chand, Prof Evan Simpson

Funding Body

Cancer Council Research Grant

Institution

Cancer Drug Discovery, Hudson Institute of Medical Research

Funding

$100,000 per annum

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