New therapeutic targets for breast cancer are urgently required. This application focuses on a protein known as LRH-1, which we have previously shown to mediate oestrogen production in breast tissues. We will show that LRH-1 stimulates breast cancer proliferation in animal and preclinical models, and demonstrate the utility of blocking LHR-1 function, using novel inhibitors, as breast cancer therapy.nuclear receptors, endocrinology, cell proliferation, transgenic mouse, mammary gland cancer.
Dr Colin Clyne, Dr Ashwini Chand, Prof Evan Simpson
Cancer Council Research Grant
Cancer Drug Discovery, Hudson Institute of Medical Research
$100,000 per annum