Interfering with a novel immune checkpoint to treat malignant melanoma

Project Description

Melanoma is responsible for the majority of skin cancer related deaths and its incidence is rising. Strategies to harness the body's own immune system have shown promising anti-tumour effects, however, only a group of patients shows a response. We identified a novel molecule in melanoma that may block the immune system from efficiently destroying the tumour. This application aims to understand and interfere with the immune-suppressive action of this protein to create new therapeutic options.

Lay Report:

Year

2015

Researchers

Dr Andreas Behren, Dr Katherine Woods, Prof Jonathan Cebon

Funding Body

Cancer Council Research Grant

Institution

Cancer Immunobiology, Olivia Newton-John Cancer Research Institute

Funding

$93,089

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